منابع مشابه
B-lymphocyte dysfunction in chronic HIV-1 infection does not prevent cross-clade neutralization breadth.
Aberrant expression of regulatory receptors programmed death-1 (PD-1) and B- and T-lymphocyte attenuator (BTLA) is linked with dysregulation and exhaustion of T lymphocytes during chronic human immunodeficiency virus type 1 (HIV-1) infection; however, less is known about whether a similar process impacts B-lymphocyte function during HIV-1 infection. We reasoned that disruption of the peripheral...
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Computational protein design has been successful in modeling fixed backbone proteins in a single conformation. However, when modeling large ensembles of flexible proteins, current methods in protein design have been insufficient. Large barriers in the energy landscape are difficult to traverse while redesigning a protein sequence, and as a result current design methods only sample a fraction of...
متن کاملHiv-1 Neutralization by Antibodies
12 Los Alamos National Laboratory and New Mexico Consortium, Los Alamos, New Mexico, United 13 States of America 14 Vaccine Research Center, National Institutes of Health, Bethesda, Maryland, United States of America 15 Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America 16 Duke University Medical Center, Durham, North Carolina, United States of America 17 US M...
متن کاملHIV-Specific B Cell Frequency Correlates with Neutralization Breadth in Patients Naturally Controlling HIV-Infection
HIV-specific broadly neutralizing antibodies (bnAbs) have been isolated from patients with high viremia but also from HIV controllers that repress HIV-1 replication. In these elite controllers (ECs), multiple parameters contribute to viral suppression, including genetic factors and immune responses. Defining the immune correlates associated with the generation of bnAbs may help in designing eff...
متن کاملNeutralization tiers of HIV-1
PURPOSE OF REVIEW HIV-1 isolates are often classified on the basis of neutralization 'tier' phenotype. Tier classification has important implications for the monitoring and interpretation of vaccine-elicited neutralizing antibody responses. The molecular basis that distinguishes the multiple neutralization phenotypes of HIV-1 has been unclear. We present a model based on the dynamic nature of t...
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ژورنال
عنوان ژورنال: Nature Medicine
سال: 2015
ISSN: 1078-8956,1546-170X
DOI: 10.1038/nm.3989